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Sahoo leads breakthrough Rutgers study in nerve repair
Originally from India, Pabitra Sahoo received his doctorate from the National Centre for Cell Science, University of Pune, India.
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Pabitra Sahoo / Image- sasn.rutgers.edu
A research team led by Indian-origin assistant professor Pabitra Sahoo at Rutgers University–Newark has achieved a significant breakthrough in nerve regeneration.
Their study, recently published in the Proceedings of the National Academy of Sciences (PNAS), reveals that targeting stress granule proteins can promote the regeneration of nerve cells in both the peripheral and central nervous systems.
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Stress granules are aggregates of proteins and RNAs that form in response to cellular stress, inhibiting protein synthesis. Sahoo's team discovered that by disrupting these granules, previously stored mRNAs are released, leading to the production of proteins essential for axon regeneration. This approach not only enhanced regeneration in mouse and rat neurons but also showed promise in human neurons cultured in laboratory settings.
"We found that the mRNA stored in these stress granules are now released and undergo translation to make the proteins that spark axon regeneration," Sahoo explained. "We’re not saying this is the solution that fixes everything, but we’ve made great progress, and this points to possible therapies."
The research team includes postdoctoral associates Meghal Desai and Manasi Agrawal. Their ongoing efforts aim to improve the stability and bioavailability of the peptide used to disrupt stress granules, with the goal of developing effective therapeutic interventions for nerve damage.
Originally from India, Sahoo received his doctorate from the National Centre for Cell Science, University of Pune, India, where he studied the connections between Wnt signaling and stress granules under the mentorship of Jomon Joseph.
He later joined Jeff Twiss's laboratory at the University of South Carolina for postdoctoral research, focusing on the role of stress granules in neurons. In the fall of 2023, Sahoo joined Rutgers University–Newark as an assistant professor in the department of biological sciences.
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